Buy cheap Cleocin

Cleocin (Clindamycin) is a lincosamide antibiotic. It is usually used to treat infections with anaerobic bacteria but can also be used to treat some protozoal diseases, such as malaria. It is a common topical treatment for acne, and can be useful against some methicillin-resistant Staphylococcus aureus (MRSA) infections.

The most severe common adverse effect of Cleocin (Clindamycin) is Clostridium difficile-associated diarrhea (the most frequent cause of pseudomembranous colitis). Although this side-effect occurs with almost all antibiotics, including beta-lactam antibiotics, it is classically linked to Cleocin (Clindamycin) use.

Cleocin (Clindamycin) is marketed alone and in combination with other drugs under various trade names, including Dalacin and Cleocin (manufactured by Pfizer), and in a foam as Evoclin and Duac (with benzoyl peroxide, made by Stiefel). It is also available as a generic drug.

Cleocin (Clindamycin) is used primarily to treat infections caused by susceptible anaerobic bacteria, including infections of the respiratory tract, septicemia and peritonitis. In patients with hypersensitivity to penicillins, Cleocin (Clindamycin) may be used to treat infections caused by susceptible aerobic bacteria as well. It is also used to treat bone and joint infections, particularly those caused by Staphylococcus aureus. Topical application of Cleocin (Clindamycin) phosphate can be used to treat mild to moderate acne.

Pharmacokinetics

Approximately 90% of an oral dose of cleocin (clindamycin) is absorbed from the gastrointestinal tract and it is widely distributed throughout the body, excluding the central nervous system. Adequate therapeutic concentrations can be achieved in bone. There is also active uptake into white blood cells, most importantly neutrophils.

Cleocin (Clindamycin) is extensively metabolised in the liver, probably by CYP3A4; some of its metabolites are active, such as N-dimethyl Cleocin (Clindamycin) and Cleocin (Clindamycin) sulfoxide. The elimination half-life is 1.5 to 5 hours. Cleocin (Clindamycin) is primarily eliminated by hepatic metabolism; after an intravenous dose of Cleocin (Clindamycin) phosphate, about 4.5% of the dose is excreted in urine as cleocin (clindamycin) and about 0.35% as the phosphate salt. The metabolites are excreted primarily in the urine.

Mechanism of action

Cleocin (Clindamycin) has a bacteriostatic effect. It interferes with bacterial protein synthesis (in a similar way to erythromycin, azithromycin and chloramphenicol), by binding preferentially to the 50S subunit of the bacterial ribosome.

The structures of the complexes between several antibiotics (including Cleocin (Clindamycin)) and a Deinococcus radiodurans ribosome have been solved by X-ray crystallography by a team from the Max Planck Working Groups for Structural Molecular Biology, and published in the journal Nature.

What is the shelf life of the pills?

• The expiry date is mentioned on each blister. It is different for different batches. The shelf life is 2 years from the date of manufacture and would differ from batch to batch depending on when they were manufactured.