Most popular quantity. Desyrel (Trazodone) is a psychoactive compound with sedative, anxiolytic, and antidepressant properties. The various manufacturers claim that the antidepressant activity becomes active in the first week of therapy. Desyrel (Trazodone) has less prominent anticholinergic (dry mouth, constipation, tachycardia) and adrenolytic (hypotension, male sexual problems) side effects than most tricyclic antidepressants.
Desyrel (Trazodone) is chemically and pharmacologically distinct from tricyclic antidepressants and tetracyclic antidepressants (for a review, see PMID: 8019056). Lacking the fused ring structures typical of these compounds, Desyrel (Trazodone) is a triazolopyridine derivative.
Desyrel (Trazodone) is well absorbed after oral administration with mean peak blood levels obtained at approximately 1 hour after ingestion. Absorption is somewhat delayed and enhanced by food. The mean blood elimination half-life is biphasic: the first phase's half-life is 3–6 hours, and the following phase's half-life is 5–9 hours. The drug is extensively metabolized with 3 or 4 major metabolites having been identified in man, some of which such as mCPP may contribute to the side effect profile of Desyrel (Trazodone). Approximately 70–75% of C14-labelled Desyrel (Trazodone) was found to be excreted in the urine within 72 hours (PMID 1037253). Desyrel (Trazodone) is highly protein-bound.
What is the shelf life of the pills?
- The expiry date is mentioned on each blister. It is different for different batches. The shelf life is 2 years from the date of manufacture and would differ from batch to batch depending on when they were manufactured.
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