Most popular quantity.
Untitled Document
Lexapro (Escitalopram) is an antidepressant of the selective serotonin reuptake inhibitor (SSRI) class. It is approved for the treatment of major depressive disorder and generalized anxiety disorder; other indications include social anxiety disorder, panic disorder and obsessive-compulsive disorder. Lexapro (Escitalopram) is the S-stereoisomer (enantiomer) of the earlier Lundbeck drug citalopram (Celexa), hence the name Lexapro (Escitalopram). Lexapro (Escitalopram) is noted for its high selectivity of serotonin reuptake inhibition and, as a result has fewer side effects not related to its serotonergic activity.
Lexapro (Escitalopram) acts by increasing intrasynaptic levels of the neurotransmitter serotonin by blocking the re-uptake of the neurotransmitter into the neuron. Of the SSRIs currently on the market Lexapro (Escitalopram) has the highest affinity for the human serotonin transporter (SERT). Remarkably, another enantiomer of citalopram (R-citalopram) counteracts to a certain degree the serotonin enhancing action of Lexapro (Escitalopram). As a result, Lexapro (Escitalopram) is a more potent antidepressant than citalopram, which is a mixture of Lexapro (Escitalopram) and R-citalopram. In order to explain this phenomenon, Sanchez proposed that Lexapro (Escitalopram) enhances its own binding via an additional interaction with another allosteric site on the transporter. Further research by the same group showed that R-citalopram also enhances binding of Lexapro (Escitalopram), and therefore the allosteric interaction cannot explain the observed counteracting effect. However, in the most recent paper the same authors again reversed their findings and reported that R-citalopram decreases binding of Lexapro (Escitalopram) to the transporter. Although allosteric binding of Lexapro (Escitalopram) to the serotonin transporter is of unquestionable research interest, its clinical relevance is unclear since binding of Lexapro (Escitalopram) to the allosteric site is at least 1000 times weaker than to the primary binding site.
What is the shelf life of the pills?
- The expiry date is mentioned on each blister. It is different for different batches. The shelf life is 2 years from the date of manufacture and would differ from batch to batch depending on when they were manufactured.
| 
