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Lopressor (Metoprolol) is a selective beta1 receptor blocker used in treatment of several diseases of the cardiovascular system, especially hypertension.
Lopressor (Metoprolol) is very low melting. Its melting point is around 45 degrees Celsius (as determined by Differential scanning calorimetry). For this reason Lopressor (Metoprolol) is always manufactured in salt form, as drugs with melting points below 100 degrees Celsius are difficult to work with in a manufacturing environment. The free base exists as a waxy white solid, where the tartrate salt is finer crystalline material.
Pharmacology:
- Cardioselective
- Moderately Lipophilic
- Without intrinsic sympathomimetic activity (ISA)
- With weak membrane stabilizing activity
- Short half-life must be taken at least twice daily or as an Slow-release preparation.
Indications:
- Essential hypertension
- Coronary heart disease (prevention of angina attacks)
- Secondary prevention after a myocardial infarction
- Treatment of heart failure.
- Migraine prophylaxis
- Adjunct in treatment of hyperthyroidism
Lopressor (Metoprolol) side effects are usually mild. Transient effects include dizziness, lightheadedness, drowsiness, tiredness, diarrhea, unusual dreams, ataxia, trouble sleeping, and vision problems. It may also reduce blood flow to the hands and feet, causing them to feel numb and cold; smoking may worsen this effect.
Serious side effects that are not to be tolerated for any length of time include symptoms of a very slow heartbeat (e.g. persistent dizziness, fainting, unusual fatigue), bluish discoloration of the fingers and toes, numbness/tingling/swelling of the hands or feet, sexual dysfunction, erectile dysfunction (impotence), hair loss, mental/mood changes, trouble breathing, cough, and increased thirst. Other highly unlikely symptoms include easy bruising or bleeding, persistent sore throat or fever, yellowing skin or eyes, stomach pain, dark urine, and persistent nausea. Symptoms of an allergic reaction include: rash, itching, swelling, severe dizziness.
What is the shelf life of the pills?
- The expiry date is mentioned on each blister. It is different for different batches. The shelf life is 2 years from the date of manufacture and would differ from batch to batch depending on when they were manufactured.
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