Buy cheap Nolvadex

Nolvadex (Tamoxifen) is an orally active selective estrogen receptor modulator (SERM) which is used in the treatment of breast cancer and is currently the world's largest selling drug for that purpose.

Nolvadex (Tamoxifen) is currently used for the treatment of both early and advanced ER+ (estrogen receptor positive) breast cancer in pre- and post-menopausal women. It is also approved by the FDA for the prevention of breast cancer in women at high risk of developing the disease. It has been further approved for the reduction of contralateral (in the opposite breast) breast cancer.

At the conclusion of the large STAR clinical study, it was reported in 2006 that raloxifene is equally effective in reducing the incidence of breast cancer, but caused fewer side effects (e.g., endometrial cancer).

The large ATAC (Arimidex, Nolvadex (Tamoxifen), Alone or in Combination) trial showed that the group that received anastrozole had significantly better clinical results after five years than the Nolvadex (Tamoxifen) group. The trial suggested that anastrozole is the preferred medical therapy for postmenopausal women with localized breast cancer that is estrogen receptor positive.

Nolvadex (Tamoxifen) is used to treat infertility in women with anovulatory disorders. A dose of 10–40 mg per day is administered in days 3–7 of a woman's cycle. In addition, a rare condition occasionally treated with Nolvadex (Tamoxifen) is retroperitoneal fibrosis.

In men, Nolvadex (Tamoxifen) is sometimes used to treat gynecomastia which arises for example as a side effect of antiandrogen prostate cancer treatment. Nolvadex (Tamoxifen) is also used by bodybuilders to prevent or reduce drug-induced gynecomastia caused by the estrogenic metabolites of anabolic steroids. Nolvadex (Tamoxifen) is also sometimes used to treat or prevent gynecomastia in sex offenders undergoing treatment by temporary chemical castration.

Finally Nolvadex (Tamoxifen) is used as a research tool to trigger tissue selective gene expression in genetically modified animals using the Cre-Lox recombination technique.

Side effects

Nolvadex (Tamoxifen) is a selective estrogen receptor modulator. Even though it is an antagonist in breast tissue it acts as partial agonist on the endometrium and has been linked to endometrial cancer in some women. Therefore endometrial changes, including cancer, are among Nolvadex (Tamoxifen)'s side effects.
For some women, Nolvadex (Tamoxifen) can cause a rapid increase in triglyceride concentration in the blood. In addition there is an increased risk of thromboembolism especially during and immediately after major surgery or periods of immobility. Nolvadex (Tamoxifen) is also a cause of fatty liver, otherwise known as steatorrhoeic hepatosis or steatosis hepatis.
A significant number of Nolvadex (Tamoxifen) treated breast cancer patients experience a reduction of libido.

A beneficial side effect of Nolvadex (Tamoxifen) is that behaves as an agonist in bone, preventing bone loss by inhibiting osteoclasts, and therefore it prevents osteoporosis. When Nolvadex (Tamoxifen) was launched as a drug, it was thought that Nolvadex (Tamoxifen) would act as an estrogen receptor antagonist in all tissue, including bone, and therefore it was feared that it would contribute to osteoporosis. It was therefore very surprising that the opposite effect was observed clinically. Hence Nolvadex (Tamoxifen)'s tissue selective action directly lead to the formulation of the concept of selective estrogen receptor modulators (SERMs)

What is the shelf life of the pills?

• The expiry date is mentioned on each blister. It is different for different batches. The shelf life is 2 years from the date of manufacture and would differ from batch to batch depending on when they were manufactured.