Buy cheap Sinequan

Sinequan (Doxepin) is a psychotropic agent with tricyclic antidepressant and anxiolytic properties. As Sinequan (Doxepin) hydrochloride it is the active ingredient in cream based preparations for the treatment of dermatological itch.

Sinequan (Doxepin) inhibits the reuptake of serotonin and noradrenaline from the synaptic cleft (dual action). The reuptake-inhibition of dopamine is very weak.

It has antagonistic effects (blockade) on a variety of postsynaptic receptors:

- Extremely strong : histaminic H1, H2
- Strong : serotonergic 5-HT2, adrenergic alpha1, muscarinic
- Moderate : serotonergic 5-HT1
- Weak : dopaminic D2, adrenergic alpha2

These effects account for the actions as well for most side-effects (sedation, hypotension, anticholinergic side-effects, weight gain). Sinequan (Doxepin) shows strong antagonism against the effects of reserpine (amine depletion) in the animal model. Like other 'classical' antidepressants it has a sodium channel blocking activity, possibly accounting for its analgesic action. Additionally, Sinequan (Doxepin) exerts a strong local-anesthetic action.

Peak plasma levels are seen 2 to 3 hours after oral dosing.

What is the shelf life of the pills?

• The expiry date is mentioned on each blister. It is different for different batches. The shelf life is 2 years from the date of manufacture and would differ from batch to batch depending on when they were manufactured.